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ChemInform Abstract: Synthesis and Cyclization of Novel Lumazine — Enediyne Chimeras.

✍ Scribed by Nakyen Choy; Keith C. Russell

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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Novel Heterocyclic Enediynes. Molecular Design, Chemical Synthesis and DNA Cleavage. -Novel 10-membered oxa-or azaenediynes such as (IV) and (IX) are prepared in short procedures from the known diynes (I) and (V). The azadiynes show effective DNA cleavage under both weakly basic and acidic conditio