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ChemInform Abstract: Synthesis and Antitumor Activity of 7-Substituted 20(RS)-Camptothecin Analogues.

โœ Scribed by S.-S. JEW; H.-J. KIM; M. G. KIM; E.-Y. ROH; Y.-S. CHO; J.-K. KIM; K.-H. CHA; K.-K. LEE; H.-J. HAN; J.-Y. CHOI; H. LEE

Book ID
112036728
Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis and antitumor activity of 7-su
Synthesis and antitumor activity of 7-substituted 20(RS)-camptothecin analogues
โœ Sang-sup Jew; Hee-Jin Kim; Myoung Goo Kim; Eun-Young Roh; Youn-sang Cho; Joon-Ky ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 190 KB

Novel water-soluble camptothecin analogues with excellent antitumor activity have been designed and synthesized by total synthesis. The analogues were evaluated for cytotoxic activity against five tumor cell lines. The most potent analogue 6e exhibited significant antitumor activity at wider range o