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ChemInform Abstract: Synthesis and Antimicrobial Activity of Halogen-Substituted 2- Benzylidene-1-(1,2,4-triazol-1-ylmethyl)cyclohexanols.

✍ Scribed by M. Z. KRIMER; V. P. TASHCHI; YU. B. KAL'YAN; F. Z. MAKAEV; YU. G. PUTSYKIN; O. YU. MOLCHANOV

Book ID: 112034372
Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 27
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199628171

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An Efficient Synthesis of 6-Substituted 2-(2H-[1,2,4]Triazol-3ylmethyl)-1,2,3,4-tetrahydro-isoquinolines. -Using a bis-alkylation of amine (V) with mesylate (VI) as the key step, title compounds such as (VII)-(IX) are easily prepared. The structure of compound (IV) is proven by X-ray analysis. -(UR