Acetylenic derivatives of quinazolinones and quinazolinediones were synthesized and evaluated for their anticonvulsant activity. Most compounds displayed seizure-antagonizing activity in the maximal electroschock test (MES test) in most cases associated with little or no acute neurotoxicity determin
ChemInform Abstract: Synthesis and Anticonvulsant Activity of Acetylenic Quinazolinone Derivatives.
β Scribed by Cyril O. Usifoh; Gerhard K. E. Scriba
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 30 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
## Synthesis and Anticonvulsant Activities of (R)-(O)-Methylserine Derivatives. -Derivatives (VI), (IX), and (XII) are prepared starting from (R)-serine derivative (I). The mixed anhydride coupling procedure leading to compound (III) proceeds stereospecifically, whereas the methylation of alcohol
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Synthesis of 5-Substituted Quinazolinone Derivatives and Their Inhibitory Activity in vitro. -Quinazolinone derivatives (IV) and their methyl esters (III) are synthesized and evaluated as nonclassical lipophilic inhibitors of thymidylate synthase (no yields are given). -(BAEK, DU-