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ChemInform Abstract: Synthesis and Anticonvulsant Activities of (R)-(O)-Methylserine Derivatives.

✍ Scribed by Shridhar V. Andurkar; James P. Stables; Harold Kohn

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199916197

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✦ Synopsis

Synthesis and Anticonvulsant Activities of (R)-(O)-Methylserine

Derivatives.

-Derivatives (VI), (IX), and (XII) are prepared starting from (R)-serine derivative (I). The mixed anhydride coupling procedure leading to compound (III) proceeds stereospecifically, whereas the methylation of alcohol (I) and the hydrolysis of esters (VII) and (XI) is accompanied by partial racemization yielding the products with only 70% e.e.. Compound (VI) exhibits modest anticonvulsant activity. -(ANDURKAR, SHRIDHAR V.;

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