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ChemInform Abstract: Structural Studies of Cytotoxic Marine Alkaloids: Synthesis of Novel Ring-E Analogues of Ascididemin and Their in vitro and in vivo Biological Evaluation.

✍ Scribed by Brent S. Lindsay; Holly C. Christiansen; Brent R. Copp


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
31
Category
Article
ISSN
0931-7597

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## 2. Synthesis and in vitro Cytotoxicity of 5-C-Substituted 20(S)-Camptothecin Analogues. -A series of several 5-substituted camptothecin analogues [cf. (II), (IV), (VI)] are synthesized from the natural alkaloid (I) and evaluated for their in vitro anticancer activity. Some of these analogues, e