ChemInform Abstract: Stereoselective Grignard-Type Reactions of Chiral N,N-Dibenzylamino Ketones.

✍ Scribed by Manfred T. Reetz; Alfred Schmitz

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199927211

✦ Synopsis

Stereoselective

Grignard-Type Reactions of Chiral N,N-Dibenzylamino Ketones.

-Enantiomerically pure N,N-dibenzylamino ketones (I), derived from chiral α-amino acids, react under nonchelating conditions with organometal reagents of type RLi, RMgX, RCeCl 2 . The reactions proceed highly diastereoselectively without racemization. -(REETZ, MAN-