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ChemInform Abstract: Short and Efficient Synthesis of the Antitumor Heptenes Melodienone and Isomelodienone.

✍ Scribed by J. BOUKOUVALAS; Y.-X. CHENG


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
29
Category
Article
ISSN
0931-7597

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The synthesis of the title compound (VI), a brasilane sesquiterpenoid alcohol, is achieved from the (R)-pulegone derivative (I) in only three steps. The key to success is the diastereoselective radical addition of the tertiary radical derived from (II) to the electrophilic radicophile (I). -(COSSY,