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ChemInform Abstract: Selective Deprotection of Phthalyl Protected Amines.

✍ Scribed by C. A. COSTELLO; A. J. KREUZMAN; M. J. ZMIJEWSKI

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

The absolute requirement for deprotection of the title amines is a two-carbon spacer between the free carboxylate and the benzoyl amine, cf. compounds (Ib) and (Ic). No enzymatic deprotection occurs if the reactive carboxylate is blocked,

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Laccase-Mediated Deprotection of para-Me
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✍ Jorge M.β€…M. Verkade; Lieke J.β€…C. van Hemert; Peter J.β€…L.β€…M. Quaedflieg; Hansβ€…E. πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 94 KB

## Abstract A novel enzymatic procedure for the oxidative deprotection of __p__‐methoxyphenyl (PMP)‐protected amines is described. By using laccases (E.C. 1.10.3.2) under mildly acidic conditions, a variety of PMP‐protected amines were successfully deprotected. The rate of deprotection was solvent‐

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✍ Jorge M. M. Verkade; Lieke J. C. van Hemert; Peter J. L. M. Quaedflieg; Hans E. πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons βš– 25 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.