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Laccase-Mediated Deprotection of para-Methoxyphenyl (PMP)-Protected Amines

✍ Scribed by Jorge M. M. Verkade; Lieke J. C. van Hemert; Peter J. L. M. Quaedflieg; Hans E. Schoemaker; Martin Schürmann; Floris L. van Delft; Floris P. J. T. Rutjes

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
94 KB
Volume
349
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

A novel enzymatic procedure for the oxidative deprotection of p‐methoxyphenyl (PMP)‐protected amines is described. By using laccases (E.C. 1.10.3.2) under mildly acidic conditions, a variety of PMP‐protected amines were successfully deprotected. The rate of deprotection was solvent‐ and pH‐dependent, and the reaction scope could be increased by using so‐called mediators.

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