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ChemInform Abstract: Selective Cleavage of Cbz-Protected Amines.

โœ Scribed by Bruce H. Lipshutz; Steven S. Pfeiffer; Anthony B. Reed


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
33
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Selective Deprotect
โœ C. A. COSTELLO; A. J. KREUZMAN; M. J. ZMIJEWSKI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 27 KB

The absolute requirement for deprotection of the title amines is a two-carbon spacer between the free carboxylate and the benzoyl amine, cf. compounds (Ib) and (Ic). No enzymatic deprotection occurs if the reactive carboxylate is blocked,