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ChemInform Abstract: Resolution of Racemic Flurbiprofen by Lipase-Mediated Esterification in Organic Solvent.

โœ Scribed by R. MORRONE; G. NICOLOSI; A. PATTI; M. PIATTELLI


Book ID
112024694
Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
27
Category
Article
ISSN
0931-7597

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Resolution of racemic flurbiprofen by li
โœ Raffaele Morrone; Giovanni Nicolosi; Angela Patti; Mario Piattelli ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 357 KB

Resolution of rac-flurbiprofen, 2-fluoro-0t-methyi-[1,1'-biphenyl]-4-scetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized l