Resolution of racemic flurbiprofen by li
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Raffaele Morrone; Giovanni Nicolosi; Angela Patti; Mario Piattelli
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Article
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1995
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Elsevier Science
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English
โ 357 KB
Resolution of rac-flurbiprofen, 2-fluoro-0t-methyi-[1,1'-biphenyl]-4-scetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized l