Resolution of rac-flurbiprofen, 2-fluoro-0t-methyi-[1,1'-biphenyl]-4-scetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized l
Enantioselective esterification of racemic naproxen by lipases in organic solvent
โ Scribed by Shau-Wei Tsai; Hwa-Jou Wei
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 550 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0141-0229
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๐ SIMILAR VOLUMES
A lipase-catalyzed enantioselective esteriยฎcation process in cyclohexane was developed for the synthesis of S( )-naproxen ester prodrugs containing the moiety of N,N-dialkylamino, ethylene glycol or alkyl ether of ethylene glycol. A high enantiomeric ratio of 44 was obtained when di(ethylene glycol
## Doubly enantioselective lipase-catalyzed esterification of racemic acids and alcohols was proceeded in n-hexane. The enantioselectivities of the lipase toward both of racemic substrates were affected reciprocally. It showed that the active site of the lipase was quite flexible.