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ChemInform Abstract: Recent Advances in Neurokinin Receptor Antagonists

โœ Scribed by Zhongli Gao; Norton P. Peet

Publisher
John Wiley and Sons
Year
2010
Weight
23 KB
Volume
30
Category
Article
ISSN
0931-7597

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High Affinity, Selective Neurokinin 2 and Neurokinin 3 Receptor Antagonists from a Common Structural Template. -Starting from a common lactam (I) two types of neurokinin receptor antagonists (IV) and (V) can be prepared by simple reaction sequences. Derivatives (V) are found to be selective potent