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ChemInform Abstract: Reaction of Some α-Oxophenylhydrazones with 2-Amino-1,1,3- tricyanopropene and Diethyl 1-Cyano-2-aminopropene-1,3-dicarboxylate: Synthesis of Polyfunctionally Substituted Pyridine, Pyridazine and Cinnoline Derivatives.

✍ Scribed by I. A. EL-SAKKA

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Reaction of Some α-Oxophenylhydrazones with 2-Amino-1,1,3tricyanopropene and Diethyl 1-Cyano-2-aminopropene-1,3dicarboxylate: Synthesis of Polyfunctionally Substituted Pyridine, Pyridazine and Cinnoline Derivatives.

-Hydrazones (I) and (VII) react with enaminonitrile (II) to yield pyridopyridine (III) and pyridopyridazine (VIII), respectively. Hydrazone (VII) also condenses with the ethyl cyanoacetate dimer (X) to yield an intermediate which reacts with ammonia liberated in the medium to yield the isolable product (XI). The activity of the methyl group in the side chain of (III) is tested by reaction with benzaldehyde (IV) followed by cyclization to give the polycyclic compound (VI). -(EL-SAKKA, I. A.; J.

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