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ChemInform Abstract: Prolinethioamides versus Prolinamides in Organocatalyzed Aldol Reactions — A Comparative Study

✍ Scribed by Dorota Gryko; Mikolaj Chrominski; Dominika J. Pielacinska


Publisher
John Wiley and Sons
Year
2011
Weight
18 KB
Volume
42
Category
Article
ISSN
0931-7597

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Prolinamides versus Prolinethioamides as
✍ Diana Almaşi; Diego A. Alonso; Carmen Nájera 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB 👁 2 views

## Abstract A solvent‐free asymmetric and direct __anti__‐aldol reaction of aliphatic ketones with aromatic aldehydes catalyzed by recyclable L‐prolineamides and L‐prolinethioamides **3** is studied. The L‐prolinethioamide **3d** (5 mol%), derived from L‐Pro and (__R__)‐1‐aminoindane, is the most e