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ChemInform Abstract: Water versus Solvent-Free Conditions for the Enantioselective Inter- and Intramolecular Aldol Reaction Employing L-Prolinamides and L-Prolinethioamides as Organocatalysts.

✍ Scribed by Diana Almasi; Diego A. Alonso; Andrea-Nekane Balaguer; Carmen Najera

Publisher
John Wiley and Sons
Year
2009
Weight
49 KB
Volume
40
Category
Article
ISSN
0931-7597

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Water versus Solvent-Free Conditions for
Water versus Solvent-Free Conditions for the Enantioselective Inter- and Intramolecular Aldol Reaction Employing L-Prolinamides and L-Prolinethioamides as Organocatalysts
✍ Diana Almaşi; Diego A. Alonso; Andrea-Nekane Balaguer; Carmen Nájera 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 1 views

## Abstract magnified image Organocatalysts **1**, derived from L‐proline and (1__S__,2__R__)‐__cis__‐1‐aminoindan‐2‐ol or (__R__)‐1‐aminoindane, are evaluated as promoters in the direct asymmetric aldol reaction between ketones and aromatic aldehydes in the presence of water and under solvent‐fre

Prolinamides versus Prolinethioamides as
Prolinamides versus Prolinethioamides as Recyclable Catalysts in the Enantioselective Solvent-Free Inter- and Intramolecular Aldol Reactions
✍ Diana Almaşi; Diego A. Alonso; Carmen Nájera 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB 👁 2 views

## Abstract A solvent‐free asymmetric and direct __anti__‐aldol reaction of aliphatic ketones with aromatic aldehydes catalyzed by recyclable L‐prolineamides and L‐prolinethioamides **3** is studied. The L‐prolinethioamide **3d** (5 mol%), derived from L‐Pro and (__R__)‐1‐aminoindane, is the most e