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ChemInform Abstract: Penicillin-Bound Proteins. The Target of β-Lactam Antibiotics. Mechanism of Action of β-Lactamases and Their Inhibitors

✍ Scribed by J. LESSEL

Book ID
112033524
Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
27
Category
Article
ISSN
0931-7597

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Conformational analysis of bacterial cell wall peptides indicates how particular conformations have influenced the evolution of penicillin-binding proteins, β-lactam antibiotics and antibiotic resistance mechanisms
✍ Barry M. Grail; John W. Payne 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 537 KB

## Abstract Our aim was to use a conformational analysis technique developed for peptides to identify structural relationships between bacterial cell wall peptides and β‐lactam antibiotics that might help to explain their different actions as substrates and inhibitors of penicillin binding proteins