ChemInform Abstract: P-Chiral Bis(trialkylphosphine) Ligands and Their Use in Highly Enantioselective Hydrogenation Reactions.

✍ Scribed by T. IMAMOTO; J. WATANABE; Y. WADA; H. MASUDA; H. YAMADA; H. TSURUTA; S. MATSUKAWA; K. YAMAGUCHI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199826044

✦ Synopsis

P-Chiral Bis(trialkylphosphine) Ligands and Their Use in Highly

Enantioselective Hydrogenation Reactions.

-The title compounds, e.g. (I), prepared from alkyl dimethyl phosphine boranes using an asymmetric deprotonation (sBuLi/(-)-sparteine) and subsequent oxidative coupling as the key steps, are found to be useful catalysts for asymmetric hydrogenation of α-(acylamino)acrylic derivatives (no yields given).

-(IMAMOTO, T.;