ChemInform Abstract: One-Pot Tandem Approach for the Synthesis of Benzothiazoles from Benzyl Halides.
โ Scribed by Chen Zhu; Takahiko Akiyama
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 29 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
Mild Kornblum conditions without any additional oxidant allow the access to the pharmacologically important heterocyclic system and a range of substituents is tolerated.
๐ SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Benzyl halides (I) or โtosylates (V) are oxidized to aldehydes under mild Kornblum conditions which then undergo a threeโcomponent reaction with various 2โaminopyridines (II) and isocyanides (III) to afford title compounds (IV)/ (VI) in high yields.
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