ChemInform Abstract: Novel and Efficient One-Pot Synthesis of N′-Alkyl-N,N-dimethylacetamidines.
✍ Scribed by Zhe-Qi Li; Hui-Long Wang
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 24 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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A number of 2-N-alkylamino-or 2-N-phenylamino-, 2-N,N-RCH 2 CϵCLi, or the lithiated allene, tBuCH=C=CHLi, and isothiocyanate, RЈN=C=S, in tetrahydrofuran and subse-dialkylamino-, and 2-N-alkyl-N-phenylaminothiophenes have been prepared in good yields by adding a solution of quently hydrolyzing the r
Mono-N-ethylated h-amino acid esters are obtained in high yields using reductive amination procedures. Formation of imine is achieved by excess of acetaldehyde, followed by removal of acetaldehyde and reduction by NaBH(OAc) 3 . The elaborated one-pot synthesis allows for the efficient synthesis of s