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ChemInform Abstract: N-Hydroxyurea and Hydroxamic Acid Inhibitors of Cyclooxygenase and 5-Lipoxygenase.

✍ Scribed by Peter J. Connolly; et al. et al.

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

N-Hydroxyurea and Hydroxamic Acid Inhibitors of Cyclooxygenase and 5-Lipoxygenase. -Among the prepared two series of N-hydroxyurea (XII) and hydroxamic acids (XVIII) potent both COX and 5-LO inhibitors are evaluated. The desired long duration inhibition of 5-LO could not be achieved.

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