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ChemInform Abstract: Molecular Design and Structure—Activity Relationships Leading to the Potent, Selective, and Orally Active Thrombin Active Site Inhibitor BMS-189664 (I).

✍ Scribed by Jagabandhu Das; S. David Kimball; et al. et al.


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
33
Category
Article
ISSN
0931-7597

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Heterocyclic-Fused 3(2H)-Pyridazinones as Potent and Selective PDE IV Inhibitors: Further Structure-Activity Relationships and Molecular Modeling Studies. -Among a variety of title compounds the derivatives (III) and (IV) emerged as the most interesting PDE IV inhibitors. Compared with Rolipram (III