ChemInform Abstract: Library Construction of 1-(1H-Imidazol-1-yl)-1,2-dihydroisoquinolines via Three-Component Reaction of 2-Alkynylbenzaldehyde, Amine, and Imidazole.
β Scribed by Honglei Lou; Shengqing Ye; Jianfeng Zhang; Jie Wu
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 41 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Library Construction of 1-(1H-Imidazol-1-yl)-1,2-dihydroisoquinolines via Three-Component Reaction of 2-Alkynylbenzaldehyde, Amine, and Imidazole. -A variety of anilines, substituted alkynylbenzaldehydes and imidazoles can be applied. No reaction takes place when a nonaromatic (benzyl) amine is used. -(LOU,
π SIMILAR VOLUMES
## Abstract The reaction proceeds highly selectively and might involve tandem condensation, nucleophilic addition and intramolecular 5βexoβcyclization.
## Abstract The previously unknown title compounds (IV) are synthesized through thermal intramolecular cyclocondensation of hydrazones (III).
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