ChemInform Abstract: Isothiazoles. Part 5. Cycloaddition Reaction of Nitrile Oxides to 3- Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-Dioxide: An Entry to 5-Acyl- and 5-Cyano-isothiazole 1,1-Dioxide Derivatives.
β Scribed by F. CLERICI; F. FERRARIS; M. L. GELMI
- Book ID
- 112028978
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reaction 5-substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interest for biological