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Isothiazoles. Part V. 1cycloaddition reaction of nitrite oxides to 3 diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide: an entry to 5-acyl- and 5-cyano-isothiazole 1,1-dioxide derivatives

✍ Scribed by Franceses Clerici; Federica Ferraris; Maria L. Gelmi


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
734 KB
Volume
51
Category
Article
ISSN
0040-4020

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A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reaction 5-substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interest for biological

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Isothiazoles. Part 9. An Efficient Synthetic Route to 5-Substituted-3-amino-4-arylisothiazole 1,1-Dioxides and Their 4,5-Dihydro Derivatives. -The thiazole dioxide (I) does not react with alcohols, while the derivative (VIII) does not undergo addition with aliphatic and aromatic amines but with the