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Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3-amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives

✍ Scribed by Egle M Beccalli; Francesca Clerici; Maria Luisa Gelmi

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
599 KB
Volume
55
Category
Article
ISSN
0040-4020

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✦ Synopsis

A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reaction 5-substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interest for biological studies.

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