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ChemInform Abstract: Highly Efficient and Stereoselective Radical Addition of Tertiary Amines to Electron-Deficient Alkenes — Application to the Enantioselective Synthesis of Necine Bases.

✍ Scribed by Samuel Bertrand; Norbert Hoffmann; Jean-Pierre Pete


Publisher
John Wiley and Sons
Year
2001
Weight
42 KB
Volume
32
Category
Article
ISSN
0931-7597

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Abstract

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ChemInform Abstract: Stereoselective Rad
✍ Samuel Bertrand; Norbert Hoffmann; Jean-Pierre Pete 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

Application to the Enantioselective Synthesis of (-)-Isoretronecanol and (+)-Laburnine. -Compound (I) is an adduct of a stereoselective radical addition of a tertiary amine with (5R)-5-menthyloxy-2[5H]-furanone. It is readily transformed to (+)-laburnine (IV) in a three-step sequence. Similarly, (-