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ChemInform Abstract: Ethyl 1,4-Dihydro-4-oxo-1,8-naphthyridine-3-carboxylates by a Tandem S N Ar-Addition-Elimination Reaction.

✍ Scribed by Bunce, Richard A.; Nammalwar, Baskar

Book ID
118755802
Publisher
John Wiley and Sons
Year
2012
Weight
33 KB
Volume
43
Category
Article
ISSN
0931-7597

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Ethyl 1,4-dihydro-4-oxo-3-quinolinecarbo
Ethyl 1,4-dihydro-4-oxo-3-quinolinecarboxylates by a tandem addition-elimination-SNAr reaction
✍ Richard A. Bunce; Eric J. Lee; Matthew T. Grant 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 196 KB

## Abstract The ethyl 1,4‐dihydro‐4‐oxo‐3‐quinolinecarboxylate ring structure, important in several drug compounds, has been prepared in two steps from ethyl 2‐(2‐fluorobenzoyl)acetate. Treatment of this β‐ketoester with __N__,__N__‐dimethylformamide dimethyl acetal gives a 97% yield of the 2‐dimet