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ChemInform Abstract: Ethyl 1,4-Dihydro-4-oxo-3-quinolinecarboxylates by a Tandem Addition—Elimination—SNAr Reaction.

✍ Scribed by Richard A. Bunce; Eric J. Lee; Matthew T. Grant

Publisher
John Wiley and Sons
Year
2011
Weight
35 KB
Volume
42
Category
Article
ISSN
0931-7597

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Ethyl 1,4-dihydro-4-oxo-3-quinolinecarbo
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## Abstract magnified image A tandem Michael‐S~N~Ar annulation reaction has been developed for the synthesis of 1‐alkyl‐2,3‐dihydro‐4(1__H__)‐quinolinones. Success in the reaction followed expected electronic effects for the final S~N~Ar ring closure. Treatment of doubly activated 1‐(2‐fluoro‐5‐ni