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ChemInform Abstract: Enantioselective Total Synthesis of (-)-Acylfulvene (IX) and (-)-Irofulven (X).

โœ Scribed by Dustin S. Siegel; Grazia Piizzi; Giovanni Piersanti; Mohammad Movassaghi


Publisher
John Wiley and Sons
Year
2010
Weight
50 KB
Volume
41
Category
Article
ISSN
0931-7597

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Enantioselective Total Synthesis of (โˆ’)-
โœ Mohammad Movassaghi; Grazia Piizzi; Dustin S. Siegel; Giovanni Piersanti ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 145 KB ๐Ÿ‘ 1 views

While sesquiterpene illudins M and S (1 and 2, respectively) are highly cytotoxic compounds isolated from Omphalotus illudens, a semisynthetic derivative, (ร€)-irofulven (4; hydroxymethyl acylfulvene (HMAF)), has recently demonstrated far superior efficacy as an antitumor agent. [1, 2] (ร€)-Irofulven