ChemInform Abstract: Electrocatalytic and Chemical Assembling of N,N′-Dialkylbarbituric Acids and Aldehydes: Efficient Cascade Approach to the Spiro-[furo [2,3-d]pyrimidine-6,5′-pyrimidine]-2,2′,4,4′,6′-(1′H,3H,3′H)-pentone Framework.
✍ Scribed by Anatolii N. Vereshchagin; Michail N. Elinson; Evgeniya O. Dorofeeva; Tatiana A. Zaimovskaya; Nikita O. Stepanov; Sergey V. Gorbunov; Pavel A. Belyakov; Gennady I. Nikishin
- Book ID
- 112046281
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 30 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Reaction of barbituric acid (I) with aromatic aldehydes is investigated in the presence of bromine under 2 different sets of reaction conditions.
Cascade assembly of N,N 0 -dialkylbarbituric acids and aldehydes in the presence of bromine leads to the selective and efficient formation of substituted 1,5-dihydro-2H,2 0 H-spiro(furo[2,3-d]pyrimidine-6,5 0pyrimidine)-2,2 0 ,4,4 0 ,6 0 -(1 0 H,3H,3 0 H)-pentones in 70-88% yields via a complex casc