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ChemInform Abstract: Discovery of S-777469: An Orally Available CB2 Agonist as an Antipruritic Agent.

✍ Scribed by Masahide Odan; et al. et al.


Book ID
112049292
Publisher
John Wiley and Sons
Year
2012
Weight
27 KB
Volume
43
Category
Article
ISSN
0931-7597

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## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.