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ChemInform Abstract: Discovery of S-444823, a Potent CB1/CB2 Dual Agonist as an Antipruritic Agent.

✍ Scribed by Masahide Odan; et al. et al.


Book ID
112049312
Publisher
John Wiley and Sons
Year
2012
Weight
22 KB
Volume
43
Category
Article
ISSN
0931-7597

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## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.