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ChemInform Abstract: Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR.

โœ Scribed by P. J. HAJDUK; G. SHEPPARD; D. G. NETTESHEIM; E. T. OLEJNICZAK; S. B. SHUKER; R. P. MEADOWS; D. H. STEINMAN; G. M. JUN. CARRERA; P. A. MARCOTTE; J. SEVERIN; K. WALTER; H. SMITH; E. GUBBINS; R. SIMMER; T. F. HOLZMAN; D. W. MORGAN; S. K. DAVIDSEN; J. B. SUMMERS; S. W. FESIK

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Discovery of Potent
ChemInform Abstract: Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors.
โœ S. PIKUL; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 2 views

Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors. -A novel series of matrix metalloproteinase inhibitors such as (I) based on 1,3-piperazine is synthesized and evaluated for the inhibition of callagenase-1, stromelysin, matrilysin, and gelatinase-B. The most active compound is (Ib).