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ChemInform Abstract: Discovery of Potent and Selective Succinyl Hydroxamate Inhibitors of Matrix Metalloprotease-3 (Stromelysin-1).

โœ Scribed by M. Jonathan Fray; Roger P. Dickinson

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
32
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Discovery of Potent
ChemInform Abstract: Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors.
โœ S. PIKUL; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 2 views

Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors. -A novel series of matrix metalloproteinase inhibitors such as (I) based on 1,3-piperazine is synthesized and evaluated for the inhibition of callagenase-1, stromelysin, matrilysin, and gelatinase-B. The most active compound is (Ib).