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ChemInform Abstract: Discovery and Evaluation of a Series of 3-Acylindole Imidazopyridine Platelet-Activating Factor Antagonists.

✍ Scribed by M. L. CURTIN; et al. et al.

Publisher: John Wiley and Sons
Year: 2010
Weight: 27 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199818164

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✦ Synopsis

Discovery and Evaluation of a Series of 3-Acylindole Imidazopyridine Platelet-Activating Factor Antagonists.

-Synthesis and evaluation of a series of indole-and benzoyl spacer-modified analogues of lead compound (I) leads to the discovery of a new potent, water-soluble, orally active and long-acting antagonist of PAF (platelet-activating factor), i.e. compound (II), which is currently in clinical evaluation. -(CURTIN, M.

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