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ChemInform Abstract: Dual Antagonists of Platelet Activating Factor and Histamine. Part 3. Synthesis, Biological Activity and Conformational Implications of Substituted N-Acyl-bis-arylcycloheptapiperazines.

✍ Scribed by John J. Piwinski; Jesse K. Wong; Michael J. Green; James J. Kaminski; Frank Colizzo; Margaret M. Albanese; Ashit K. Ganguly; M. Motasim Billah; John C. Anthes; Robert E. West Jr.

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. Part 3. Synthesis of (Β±)-N-[2-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and Evaluation of NK 1 -NK 2 Dual Antagonistic Activities. -In order to obtain more potent NK 1 -NK 2 dual antagonists a