ChemInform Abstract: Discovery and Evaluation of Potent, Tyrosine-Based α4β1 Integrin Antagonists.
✍ Scribed by Sarah C. Archibald; John C. Head; Neil Gozzard; David W. Howat; Ted A. H. Parton; John R. Porter; Martyn K. Robinson; Anthony Shock; Graham J. Warrellow; William M. Abraham
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and
The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and