ChemInform Abstract: Diastereoselective Triple Radical Cyclization of a Bromomethyldimethylsilyl Allyl Ether.
β Scribed by A. S. KENDE; M. JOURNET; R. G. BALL; N. N. TSOU
- Book ID
- 112040953
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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Regio-and Stereospecificity in Radical Cascade Cyclizations of TMS-Alcyne Containing Allyl Bromomethyldimethylsilyl Ethers. -Tandem radical cyclization of the racemic (E)-silane (I) yields the all-cis substituted vinylcyclopentanol (II) as an isoprostanoid precursor together with minor amounts of t
5-Endo-trig Radical Cyclizations of Bromomethyldimethylsilyl Diisopropylpropargylic Ethers. A Highly Diastereoselective Access to Functionalized Cyclopentanes. -The title ethers (I), (V) and (VIII) undergo a radical-induced 5-exo-dig cyclization-diastereoselective 1,5-hydrogen transfer-5-endo-trig
Tandem radical cyclization of (E) and (Z) TMS-homopropargyl allyl brumomethyldimethylsilyl ethers is reported to provide an ail-cis substituted vinylcyclopentanol 5. Regio-and stereospecificity are discussed.