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ChemInform Abstract: Design and Synthesis of Bio-Isosteres of Thymidine Triphosphate.

✍ Scribed by A. O. GOLDRING; J. BALZARINI; I. H. GILBERT

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Design and Synthesis of Bio-Isosteres of Thymidine Triphosphate.

-First metabolic stable and lipophilic triphosphate isosteres are prepared and subsequent linked to nucleosides such as (VIII) and (IX) derived from pyrrole (VII). None of the products show surprisingly the desired anti-HIV activity. -(GOLDRING, A.

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