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ChemInform Abstract: Isosteres of Nucleoside Triphosphates.

✍ Scribed by R. WEAVER; I. H. GILBERT; N. MAHMOOD; J. BALZARINI

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
28
Category
Article
ISSN
0931-7597

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Design and Synthesis of Bio-Isosteres of Thymidine Triphosphate. -First metabolic stable and lipophilic triphosphate isosteres are prepared and subsequent linked to nucleosides such as (VIII) and (IX) derived from pyrrole (VII). None of the products show surprisingly the desired anti-HIV activity.