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ChemInform Abstract: Circular Dichroism Studies of Bisindole Vinca Alkaloids.

✍ Scribed by Craig A. Parish; Jian-Guo Dong; William G. Bornmann; Joan Chang; Koji Nakanishi; Nina Berova

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
30
Category
Article
ISSN
0931-7597

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The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-