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ChemInform Abstract: Chemical Synthesis and Evaluation of 17α-Alkylated Derivatives of Estradiol as Inhibitors of Steroid Sulfatase.

✍ Scribed by Diane Fournier; Donald Poirier

Publisher: John Wiley and Sons
Year: 2012
Weight: 45 KB
Volume: 43
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201205213

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ChemInform Abstract: Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase.

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Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase. -A series of pyrrolebutyric acid derivatives (I) (37 examples) are synthesized and evaluated for their inhibitory activity on steroid 5α-reductase in vitro and ex vivo. The calcium salt of (Id) shows potent inhibitory activities