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ChemInform Abstract: Ceric Ammonium Nitrate Promoted Free Radical Cyclization Reactions Leading to β-Lactams.

✍ Scribed by A. D'ANNIBALE; A. PESCE; S. RESTA; C. TROGOLO


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


Ceric Ammonium Nitrate Promoted Free Radical Cyclization Reactions Leading to β-Lactams.

-Treatment of enamides (I) or (V) with cerium ammonium nitrate (CAN) generates α-carbamoyl radicals which undergo 4-exo-trig cyclization followed by methanol quenching to provide the functionalized β-lactams. This is the first example of the use of amides in CAN promoted radical generation. -(D'


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