ChemInform Abstract: Catalytic, Asymmetric Hypervinylogous Mukaiyama Aldol Reactions of Extended Furan-Based Silyl Enolates.
✍ Scribed by Claudio Curti; Lucia Battistini; Andrea Sartori; Alessio Lodola; Marco Mor; Gloria Rassu; Giorgio Pelosi; Franca Zanardi; Giovanni Casiraghi
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 42 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Denmark’s chiral bisphosphoramide/silicon tetrachloride system performs as an excellent Lewis base‐Lewis acid catalyst for the vinylogous Mukaiyama aldol reaction of pyrrole‐ and furan‐based dienoxy silanes with aromatic and heteroaromatic aldehydes. This asymmetric methodology provides
## Abstract The cyclic ether (I) reacts in the presence of PNO with a variety of aldehydes and ketones the give vinylogous aldols as masked δ‐hydroxy‐β‐ketoesters.