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ChemInform Abstract: Asymmetric Synthesis. Part 37. Synthesis of 2,6-Disubstituted Piperazines from Chiral Non-Racemic Lactams

✍ Scribed by V. SCHANEN; M.-P. CHERRIER; S. J. DE MELO; J.-C. QUIRION; H.-P. HUSSON

Book ID
112040770
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
27
Category
Article
ISSN
0931-7597

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Stereoselective synthesis of 2,6-disubst
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✍ Estelle Bouron; GΓ©raldine Goussard; Christophe Marchand; Martine Bonin; Xavier P πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 241 KB

Optically pure 2,6-disubstituted morpholines 11 have been obtained by diastereoselective alkylation of 6-substituted 3-oxo morpholines I derived from (R)-(-)-phenylglycinol and a series of chiral epoxides.