ChemInform Abstract: Synthesis of (+)-(R
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Masayuki Kirihara; Tomofumi Takuwa; Masashi Kawasaki; Hiroko Kakuda; Shun-ichi H
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Article
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2010
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John Wiley and Sons
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Synthesis of (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid Through Lipase-Catalyzed Asymmetric Acetylation. -Hydrochloride (VIII) of the title compound is prepared via the asymmetric acetylation of diol (III) as the key step. Several enzymes and conditions are investigated to obtain th