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ChemInform Abstract: Synthesis of (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid Through Lipase-Catalyzed Asymmetric Acetylation.

✍ Scribed by Masayuki Kirihara; Tomofumi Takuwa; Masashi Kawasaki; Hiroko Kakuda; Shun-ichi Hirokami; Hiroki Takahata

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid Through Lipase-Catalyzed Asymmetric Acetylation.

-Hydrochloride (VIII) of the title compound is prepared via the asymmetric acetylation of diol (III) as the key step. Several enzymes and conditions are investigated to obtain the chiral monoacetate (V) with high enantiomeric excesses in this reaction.

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