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ChemInform Abstract: Asymmetric Synthesis of Both Enantiomers of 2-(Dimethylamino)-1-[3-methoxy-2-(1-methylethoxy)phenyl]ethanol.

✍ Scribed by C. PHILIPPO; E. FETT; P. BOVY; M. BARRAS; I. ANGEL; G. GEORGES; P. OCHSENBEIN

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Asymmetric Synthesis of Both Enantiomers of 2-(Dimethylamino)-1-[3-methoxy-2-(1-methylethoxy)phenyl]ethanol.

-The synthesis of both enantiomers of the title compound (IX) based on the Sharpless asymmetric dihydroxylation of the vinylbenzene (IV) is described. Evaluation of their in vitro uroselectivity shows that the (S)-(+)-enantiomer is significantly more potent than the optical antipode.

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